#Nature

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背包健客
3个月前
AI发现人体内天然减肥分子，媲美“司美格鲁肽”且无副作用 2025 年 3 月 5 日，斯坦福大学医学院 Katrin Svensson 团队在国际顶尖学术期刊「Nature」上发表研究论文。 研究体开发了一种基于 AI 算法的多肽预测器（Peptide Predictor），系统性绘制了此前未被表征过的由前激素转化酶切割产生的 2683 种多肽，从中识别出新型生物活性多肽，其中一种仅 12 个氨基酸的多肽——BRP（BRINP2-related peptide），其具有与司美格鲁肽相当的抑制食欲和减轻体重的作用，但没有出现司美格鲁肽等 GLP-1 类药物的常见副作用（例如恶心、厌食、肌肉量显著减少等）。 该研究利用 AI 技术发现了一种新型天然多肽分子，其通过与 GLP-1 类药物不同的通路发挥作用，激活下丘脑中调控食欲和代谢的神经元，有望带来更具针对性、更安全的减肥方法。 针对这一发现，Katrin Svensson 创办了一家名为 Merrifield Therapeutics 的公司，计划在不久的将来在人体中开展临床试验。
#AI #减肥 #司美格鲁肽 #斯坦福大学 #Nature #多肽预测器 #生物活性多肽 #前激素转化酶 #Katrin Svensson
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《Nature》发布全球机构撤稿率排名，济宁市第一人民医院在撤稿率排行榜上位居榜首，2014年-2024年间，其总发表论文中有超过5%被撤稿，共计100多篇。是全球平均水平的50倍。 分列撤稿率榜单二三名的是河北沧州市中心医院、河南大学淮河医院，撤稿率约为3.5%左右。在撤稿率前十的机构中，中国机构占据七席，均是医院以及医学院。 根据Dimensions的数据，在撤稿率超过1%的136家机构中，大约70%为中国机构，其中接近60%为医院或医科大学。 济宁市第一人民医院早在数年前就出现大规模的学术不端事件 。2020年，加州学术诚信调查员伊丽莎白·比克发现了400 多篇内容高度雷同，疑似来自统一论文工厂的论文，这些论文几乎全部来自中国的几十家医院，其中济宁市第一人民医院的论文最多，超过100篇。 。
#Nature #机构撤稿率 #济宁市第一人民医院 #学术不端 #论文撤稿 #中国医院 #科研诚信
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The Spectator Index
5个月前
Tripadvisor best nature destinations, 2024. 1.🇳🇵 Kathmandu, Nepal 2. 🇻🇳 Halong Bay, Vietnam 3. 🇪🇬 Hurghada, Egypt 4. 🇲🇺 Mauritius 5. 🇮🇩 Lombok, Indonesia 6. 🇺🇸 Kauai, US 7. 🇹🇿 Zanzibar Island 8. 🇰🇾 Grand Cayman 9. 🇬🇵 Guadeloupe 10. 🇿🇦 Kruger National Park, South Africa
#Tripadvisor #Nature #destinations #Kathmandu #Nepal #Halong Bay #Vietnam #Hurghada #Egypt #Mauritius #Lombok #Indonesia #Kauai #US #Zanzibar Island
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The Figen
5个月前
Cats watching natural life like a documentary. 😂
#cats #Nature #Documentary #funny
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The Figen
5个月前
What a glorious wolf howling.
#Wolf #howling #Nature #wildlife #Animals
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Wild Clips
5个月前
Flight of the Shima Enaga, a Japanese bird who looks like a cotton ball
#ShimaEnaga #JapaneseBird #Nature #CottonBallBird
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The Figen
5个月前
Even though giraffes look like giants, they are one of the gentlest animals.
#giraffe #wildlife #gentle_giants #Nature #Animals
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January 21st I am walking along the Tuhai River, a familiar companion in my hometown. The weather is far from pleasant—mist hangs in the air, and the light at noon is dim, filtered weakly through a gray haze. The air quality leaves much to be desired. Still, I find solace in my steps. Walking 10,000 steps a day is not just a habit but an anchor in my life, an essential task that restores me, both body and mind. Walking energizes me, sparks ideas, and makes me feel alive. Yet, despite the rhythm of my footsteps, my writing falters. I’m caught in the grip of writer’s block, unable to think clearly or write with vigor. The act of confronting the page feels unbearable. Each morning, I wake with a heavy reluctance to write, a quiet dread that casts a shadow over the day. I don’t want to talk; I don’t even want to connect with my family. This mood—so heavy, so stubborn—seems inexplicable. Perhaps it’s a side effect of the medication I take, or maybe it’s simply the ebb of my spirit. I am moody in the mornings, unmotivated and dry, as if every wellspring of imagination has been sealed shut. I long to start fresh, to rediscover the diligence and inspiration that once came so naturally. There is so much to write, so much to explore and share, yet I feel parched, adrift in a desert of empty thoughts. If only I could find the source again, the spark of creativity, the joy of weaving words. Even in this state, I remind myself of my calling. Writing is my work, my career, my fate. It is what I must do, even when I resist it, even when it feels impossible. To write is to live, and though my thoughts now seem scattered and frail, I must shape them into something that can stand. For the first time, I am speaking these thoughts aloud in English, leaning on AI to help me sort through the tangle in my mind. I want my words to be clear, readable, and true. This is my profession, and though it is often lonely, it is mine. Walking helps me carry the weight, step by step. Writing, though difficult, is how I find my way back.
#TuhaiRiver #hometown #Nature #weather #Walking
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Wild Clips
5个月前
The sky was a paid actor
#Sky #paidactor #Metaphor #Nature #CreativeWriting
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NO CONTEXT HUMANS
5个月前
Strength of a lioness vs 3 men 🤯
#strength #lioness #comparison #men #power #Nature #wildlife #Animals
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NO CONTEXT HUMANS
5个月前
This camel can effortlessly eat sharp cactus
#Camel #Cactus #animal #Nature
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This is next level bird watching
#bird_watching #next_level #outdoor_activities #Birds #Nature #wildlife
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NO CONTEXT HUMANS
5个月前
Omg it's a class of baby goats 😍
#babygoats #cuteanimals #adorable #Nature #farmlife
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NO CONTEXT HUMANS
5个月前
That's the circle of life
#life #philosophy #Nature #circleoflife #existentialism
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The Figen
5个月前
These two little birds are living their best winter lives, perched on a bicycle pedal, watching the snow fall. 😂
#Birds #winter #bicycle #snow #Nature #Animals
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NO CONTEXT HUMANS
5个月前
I can watch this for hours 🌳
#Nature #relaxation #trees #Outdoors #peaceful
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The amount of jellyfish is crazy
#jellyfish #marine_life #ocean #environment #Nature
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Cabin in Alaska for rent, lovely view.
#Alaska #cabin #rental #Vacation #Nature #travel
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The Figen
5个月前
A mesmerizing sunrise view from Everest.
#Everest #Sunrise #Nature #travel #Mountains
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Wild Clips
5个月前
Dude wakes up in his tent and discovers this 😳
#tent #discovery #morning_surprise #camping #unexpected_event #wilderness #Outdoors #Nature
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NO CONTEXT HUMANS
5个月前
❌ Australia ✅ Zoostralia
#Australia #Zoostralia #Animals #wildlife #Nature
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Figen
6个月前
Defying the laws of physics ...
#Physics #science #defiance #laws_of_physics #Nature #impossibility #innovations
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Figen
6个月前
This is how a dandelion forms.
#dandelion #Nature #botany
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Cuddle time with a huge Anaconda 😳
#CuddleTime #Anaconda #wildlife #Snakes #Nature
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NO CONTEXT HUMANS
6个月前
Collective intelligence of ants solving a puzzle
#CollectiveIntelligence #Ants #PuzzleSolving #Nature #Biology #animalbehavior